Swiss fourth seed Wawrinka beat the 18-year-old 7-6 (7-4) 6-1 6-7 (2-7) 6-4.
Argentina's Del Potro, winner of the 2009 US Open, saw off France's Stephane Robert 6-1 7-5 6-0.
Del Potro is playing in his first Grand Slam since the 2014 Australian Open after a series of wrist surgeries.
Meanwhile, British number one Andy Murray, who beat Liam Broady 6-2 6-3 6-4, will next play Yen Hsun Lu after the Taiwanese player defeated Alexander Kudryavtsev of Russia 6-4 6-1 6-4.
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